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What in the World is
Stiff Person

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In the United States, a rare (or orphan) disease is defined by the National Organization of Rare Diseases (NORD) as a disorder affecting less than 200,000 Americans (approximately 1 in 1,500 individuals). One such rare disease is believed to affect only 1 in 1,000,000 individuals, worldwide. 

This orphan is known as Stiff Person Syndrome (SPS)

Although actually an Autoimmune Disease, it is most often treated by a Neurologist. It is characterized by rigidity
and/or spasticity of the skeletal muscles, tremors, and anxiety. The result of constant spasms is unrelenting pain and commonly, eventual disability. As SPS progresses, virtually no muscle is spared from spasms, and these may be violent enough to result in torn muscle tissue or broken bones. Frequent falls are common among those with SPS, as they lack normal balance. These falls can be serious due to an inability to react, and muscles may become rigid during the crisis.

Unique to SPS is a hyper-excitability of the muscles, known as the startle response. Emotional stress, a sudden, unexpected noise, or even a gentle touch, are known to set off prolonged, often severe, spasms, extreme rigidity, and often mistaken for a seizure.

Average time to diagnose the disease is 7 years, and misdiagnoses during this period include:

Anxiety (Conversion) Disorder, Phobia, Multiple Sclerosis, Dystonia,
PTSD, Fybromialgia, Parkinson's Disease, and Psychosomatic Illness

It is discouraging that a lack of awareness of Stiff Person Syndrome
is responsible for this prolonged delay in diagnosis.

The cause of SPS is unknown, and there is no cure. It has been theorized that SPS may be caused by a virus
which enters the brain and CSF, and introduces elevated levels of the auto-antibody, glutamic acid
decarboxylase (GAD65), preventing adequate production of gamma-Aminobutyric acid (GABA) in the brain. This
is a crucial neurotransmitter, and one of the body's natural anti-anxiety chemicals

Diagnosis is most often made from a blood test which reveals even the slightest elevated level of GAD65,
although an undetermined percentage will eventually be diagnosed without any elevation of GAD65.

There are treatments which can relieve the patient of some pain, spasticity, and anxiety. These treatments may slow the progression of the disease but it is rarely halted, and disability can be delayed, although once a patient has become wheelchair-bound it is doubtful the disability will be reversed.

Common treatments for Stiff Person Syndrome symptoms include:

High doses of Valium (Diazepam) and/or Ativan (Lorazepam) for anxiety and muscle spasms

Baclofen, a muscle relaxant (often dispensed from an implanted pump, called Intrathecal Baclofen*)

Neurontin (Gabapentin), a seizure medicine, and

Intravenous Immunoglobulin (IVIg), made from thousands of healthy blood donors for a single dose, to help negate some of the effects of GAD antibodies, and contribute to the production of GABA.

These treatments will be required for the life of the patient, in varying doses and frequency.

Other Autoimmune Diseases, including Diabetes Mellitus, Thyroiditis, Lupus, and Pernicious Anemia, are commonly found in those with Stiff Person Syndrome.
Depression is common and difficult to treat due to Neurological side effects from most Antidepressants, exacerbating SPS symptoms.


This page was created by a person with SPS, and should not be considered medical advice.
Carl David Ericson - Las Vegas, Nevada, USA. (Last modified 25 July 2015)